http://www.dore.co.uk/research/aspergers.aspx
原文如下:
US National Library of MedicineNational Institutes of Health 美國國家圖書館醫學 國立衛生研究院
Altered cerebellar feedback projections in Asperger syndrome.
Source
Section of Brain Maturation, Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, London, SE58AF, UK. m.catani@iop.kcl.ac.uk
Abstract
It has been proposed that the biological basis of autism spectrum disorder includes cerebellar 'disconnection'. However, direct in vivo evidence in support of this is lacking. Here, the microstructural integrity of cerebellar white matter in adults with Asperger syndrome was studied using diffusion tensor magnetic resonance tractography. Fifteen adults with Asperger syndrome and 16 age-IQ-gender-matched healthy controls underwent diffusion tensor magnetic resonance imaging. For each subject, tract-specific measurements of mean diffusivity and fractional anisotropy were made within the inferior, middle, superior cerebellar peduncles and short intracerebellar fibres. No group differences were observed in mean diffusivity. However, people with Asperger syndrome had significantly lower fractional anisotropy in the short intracerebellar fibres (p<0.001) and right superior cerebellar (output) peduncle (p<0.001) compared to controls; but no difference in the input tracts. Severity of social impairment, as measured by the Autistic Diagnostic Interview, was negatively correlated with diffusion anisotropy in the fibres of the left superior cerebellar peduncle. These findings suggest a vulnerability of specific cerebellar neural pathways in people with Asperger syndrome. The localised abnormalities in the main cerebellar outflow pathway may prevent the cerebral cortex from receiving those cerebellar feedback inputs necessary for a successful adaptive social behaviour.
這篇的中文大意是說：
有人曾經提過，自閉症及亞斯伯格症的生理基礎中，包含了小腦斷線這一個情況。但始終缺乏直接有力的證據。 於是他們設計了一個實驗來研究這部分，使用擴散張量磁共振的造影技術。
研究結果發現，亞斯柏格的患者確實在小腦神經連結上有一些漏洞，這個漏洞會導致某些大腦皮層的回饋訊息被阻斷，可能因而影響到其在人際社交上的行為。
